1. What is the I/T Ratio?

The I/T (Immature to Total neutrophil) ratio is a hematologic parameter used to assess neonatal sepsis. It compares the number of immature neutrophils to the total neutrophil count in a newborn's blood sample.

2. How Does the Calculator Work?

The calculator uses the simple formula:

Where:

• \( I \) — Immature neutrophil count
• \( T \) — Total neutrophil count

Explanation: The ratio provides insight into the bone marrow's response to infection, with higher ratios suggesting more significant infection.

3. Importance of I/T Ratio in Neonates

Details: The I/T ratio is particularly valuable in neonatal medicine as part of sepsis evaluation. Ratios >0.2-0.3 are often considered abnormal and may indicate infection.

4. Using the Calculator

Tips: Enter both immature neutrophil count (I) and total neutrophil count (T) in the same units (typically absolute counts). Both values must be positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal I/T ratio in neonates?
A: Typically <0.2 in healthy term infants. Values >0.2-0.3 suggest possible infection.

Q2: How is the I/T ratio used clinically?
A: It's part of the sepsis evaluation in newborns, often combined with other tests like CRP and clinical assessment.

Q3: Does gestational age affect the I/T ratio?
A: Yes, premature infants may have slightly higher normal ranges than term infants.

Q4: What are the limitations of the I/T ratio?
A: It has moderate sensitivity and specificity for sepsis. Clinical correlation is always needed.

Q5: How quickly does the I/T ratio change with infection?
A: It typically rises within 6-12 hours of infection onset, making it useful for early detection.