1. What is Rituximab 375 mg/m²?

Rituximab is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. The standard dose is 375 mg per square meter of body surface area (BSA).

2. How Does the Calculator Work?

The calculator uses the formula:

Where:

• 375 mg/m² — Standard rituximab dose per body surface area
• BSA — Body surface area in square meters

Explanation: The calculation multiplies the standard dose by the patient's body surface area to determine the appropriate individual dose.

3. Importance of BSA-Based Dosing

Details: BSA-based dosing helps account for differences in body size, ensuring adequate drug exposure while minimizing toxicity.

4. Using the Calculator

Tips: Enter the patient's body surface area in m². The value must be valid (BSA > 0).

5. Frequently Asked Questions (FAQ)

Q1: How is BSA calculated?
A: BSA is typically calculated using formulas like Mosteller, DuBois, or Haycock, based on height and weight.

Q2: Is this dose used for all indications?
A: While 375 mg/m² is common for many indications, some protocols use different doses or schedules.

Q3: Are there maximum dose limits?
A: Some protocols cap the dose at 1000 mg regardless of BSA calculation.

Q4: How often is this dose administered?
A: Frequency depends on the indication, ranging from weekly to every 6 months.

Q5: What about pediatric patients?
A: Pediatric dosing may differ and should follow specific pediatric protocols.