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Rituximab Infusion Protocol:
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The standard rituximab infusion protocol starts at 50 mg/hr, with rate increases of 50 mg/hr every 30 minutes to a maximum of 400 mg/hr. This gradual titration helps minimize infusion-related reactions.
The calculator follows the standard rituximab infusion protocol:
Explanation: The calculator determines whether to maintain or increase the current infusion rate based on how long the patient has been at their current rate.
Details: Gradual titration is crucial to minimize infusion reactions which can include fever, chills, rigors, and rarely more severe reactions. The protocol allows for monitoring and intervention if needed.
Tips: Enter the current infusion rate (50-400 mg/hr) and how many minutes the patient has been at this rate. The calculator will recommend whether to continue or increase the rate.
Q1: What if the patient has a reaction during infusion?
A: Slow or stop the infusion and manage symptoms. May restart at 50% of previous rate once symptoms resolve.
Q2: Are premedications required?
A: Yes, typically acetaminophen, diphenhydramine, and sometimes corticosteroids are given before infusion.
Q3: Can the rate be increased faster than every 30 minutes?
A: Only if the patient has previously tolerated rituximab well. First infusions should follow standard protocol.
Q4: What about subcutaneous rituximab?
A: Subcutaneous administration has different protocols and this calculator doesn't apply to those formulations.
Q5: How long does a full infusion take?
A: Typically 4-6 hours for first infusion, 3-4 hours for subsequent infusions when maximum rate is achieved.